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Heart and spleen twin grafts in rats. II. Delayed host splenectomy
Author(s) -
Tauber Jürg W.,
Blanchard Jacqueline M.
Publication year - 1981
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.1920020407
Subject(s) - splenectomy , medicine , spleen , surgery , transplantation , host (biology) , biology , ecology
Simultaneous auxiliary transplantation of the spleen has been shown to delay and attenuate the rejection of cardiac grafts in rats. 1 In the experiments reported here, 144 such twin grafts in Lewis and ACI rats were explored in an attempt to determine whether removal of the host's spleen would further facilitate graft survival in this model. Thus, 87 rats were submitted to host splenectomy at various time intervals after implantation of the twin grafts. After considerable technical problems were overcome, it was found that this additional maneuver induced permanent ( >5 months) survival in 64% of Lewis‐to‐ACI twin grafts. The important requirement for this success was timing; delaying host splenectomy for 3 to 5 days after implantation of the twin graft was mandatory.