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Liver microcirculation after selective denervation
Author(s) -
Pedrosa Marcelo E.,
Montero Edna F.S.,
Nigro Amaury J.T.
Publication year - 2001
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.1031
Subject(s) - medicine , denervation , microcirculation , surgery
Microcirculatory disturbances have been related to a decrease in survival after liver transplant. Because innervation is involved in liver hemodynamics regulation, we decided to evaluate microcirculatory hepatic perfusion. Thirty rats were divided into three groups: denervated (DG), hepatic microsurgical denervation; manipulated (MG), hepatic manipulation; control (CG), laparotomy. Hepatic microcirculation was assessed in the median lobe using laser Doppler flowmetry in the following moments: T 0 , after laparotomy and T 1 , after denervation; and in the following moments after denervation: T 2 , 10 minutes, T 3 , 20 minutes, T 4 , 30 minutes, T 5 , 1 hour, T 6 , 1.5 hours, and T 7 , 2 hours for DG, and in same moments for MG and CG. DG showed a decrease in hepatic perfusion for 20 minutes after denervation, different from MG and CG. After that, there was recovery in hepatic perfusion in MG and DG (Kruskal‐Wallis and Friedman tests). Therefore, denervation and manipulation alter hepatic microcirculation, but denervation promotes a more severe decrease than manipulation. © 2001 Wiley‐Liss, Inc. MICROSURGERY 21:163–165 2001