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Observations of rat ovarian‐splenic consecutive transplants
Author(s) -
Hong I.C.,
Lee S.,
Yoo C.H.,
Nam S.,
Bai S.,
Kim K.,
Pivetti C.D.,
Niewiadomski S.T.,
Wolf P.,
Gittes R.F.
Publication year - 2003
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.10186
Subject(s) - medicine , ovary , spleen , transplantation , dysgerminoma , life span , ovarian tissue , pathology , surgery , gerontology
Abstract We examined the results after implantation of ovarian follicles by various modes in a total of 82 cases. One or five ovarian follicles were implanted into spleens in castrated female rats. In 20 cases among these, each five follicles were implanted into native and transplanted spleens after spleen transplantation (double implantation of the ovary). Through consecutive spleen transplantation, we observed the results beyond the rat's life span for a limited period. In many cases, we found a more aggressive form of malignant tumor, i.e., dysgerminoma. We present the results and discuss the modes of implantations and possible pathogenetic mechanisms of tumor formation. © 2003 Wiley‐Liss, Inc. MICROSURGERY 23:450–453 2003