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Local heparin is superior to systemic heparin in preventing arterial thrombosis
Author(s) -
Andresen Dorthe M.,
Barker John H.,
Hjortdal Vibeke E.
Publication year - 2002
Publication title -
microsurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 63
eISSN - 1098-2752
pISSN - 0738-1085
DOI - 10.1002/micr.10048
Subject(s) - medicine , heparin , partial thromboplastin time , thrombosis , thrombus , activated clotting time , antithrombotic , anesthesia , saline , bolus (digestion) , isotonic saline , surgery , coagulation
Thrombosis poses a significant problem in microvascular surgery, despite antithrombotic therapy. The purpose of the present study was to investigate whether a topical application of unfractionated heparin is equally efficient as a systemic bolus in avoiding thrombosis. A rat femoral artery model was used. Three different doses of systemic heparin (50, 100, and 200 U/kg) and one dose of locally administered heparin (100 U/ml) were evaluated and compared to a control group receiving isotonic saline. A thrombogenic injury, simulating poor microsurgical technique, was applied to the artery. The thrombus area was visualized by transillumination, and recorded for 60 min on video, for subsequent measurement. In addition, the level of activated partial thromboplastin time (APTT) and of anti‐activated clotting factor X (aXa) was determined. Local heparin significantly reduced thrombus size as compared to isotonic saline and systemic heparin (50 and 100 U/kg). High‐dose systemic heparin (200 U/kg) was equally potent, but local heparin had significantly less influence on the hemostatic parameters.© 2002 Wiley‐Liss, Inc. MICROSURGERY 22:265–272 2002