Open AccessAssociation of IL‐10 ‐1082A/G polymorphism with cardiovascular disease risk: Evidence from a case–control study to an updated meta‐analysis
Author(s) -
Lu Shijuan,
Zhong Jianghua,
Huang Kang,
Zhou Honghao
Publication year - 2019
Publication title -
molecular genetics and genomic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.765
H-Index - 29
ISSN - 2324-9269
DOI - 10.1002/mgg3.888
Subject(s) - meta analysis , odds ratio , genetic model , allele , confidence interval , medicine , genotype , publication bias , heterozygote advantage , case control study , single nucleotide polymorphism , gastroenterology , genetics , gene , biology
Background Previous studies have generated controversial results about the association of interleukin 10 ( IL‐10 ) gene polymorphisms (−1082G/A) in the progression of cardiovascular disease (CVD). Therefore, this study processed a systemic meta‐analysis to verify this association. Methods The publication studies on the IL‐10 (−1082G/A) polymorphism and CVDs risk were obtained by searching PubMed and Embase databases. We analyzed the genotype data for meta‐analysis. The results were evaluated by odds ratios (ORs) and 95% confidence intervals (CIs). Meanwhile, our meta‐analysis was also performed sensitivity analyses, heterogeneity test, and identification of publication bias. Results The present meta‐analysis suggested that the risk with allele G is lower than with allele A for CVD. The G allele of IL‐10 (−1082) could increase the risk of CVDs in the 31 case–control studies for all genetic models. (OR = 1.10, 95% CI: 1.04–1.15 for the allele model A vs. G; OR = 0.87, 95% CI: 0.72–1.04 for the dominant model GG+AG vs. AA; OR = 1.03, 95% CI: 1.02–1.05 for the recessive model GG vs. AG + AA; OR = 1.06, 95% CI = 1.03–1.10 for the homozygote comparison model GG vs. AA; and OR = 0.88, 95% CI = 0.73–1.06 for the heterozygote comparison model AG vs. AA). Conclusions In genetic models, the association between the IL‐10 (−1082G/A) polymorphism and CVDs risk was significant. This meta‐analysis proposes that the IL‐10 (−1082G/A) polymorphism may serve as a risk factor for CVDs.