Open AccessAssociation of the c.385C>A (p.Pro129Thr) polymorphism of the fatty acid amide hydrolase gene with anorexia nervosa in the Japanese population
Author(s) -
Ando Tetsuya,
Tamura Naho,
Mera Takashi,
Morita Chihiro,
Takei Michiko,
Nakamoto Chiemi,
Koide Masanori,
Hotta Mari,
Naruo Tetsuro,
Kawai Keisuke,
Nakahara Toshihiro,
Yamaguchi Chikara,
Nagata Toshihiko,
Ookuma Kazuyoshi,
Okamoto Yuri,
Yamanaka Takao,
Kiriike Nobuo,
Ichimaru Yuhei,
Ishikawa Toshio,
Komaki Gen
Publication year - 2014
Publication title -
molecular genetics and genomic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.765
H-Index - 29
ISSN - 2324-9269
DOI - 10.1002/mgg3.69
Subject(s) - fatty acid amide hydrolase , single nucleotide polymorphism , allele , minor allele frequency , snp , odds ratio , genotype , genetics , polymorphism (computer science) , biology , medicine , gene , receptor , cannabinoid receptor , agonist
Abstract The functional c.385C>A single‐nucleotide polymorphism ( SNP ) in the fatty acid amide hydrolase ( FAAH ) gene, one of the major degrading enzymes of endocannabinoids, is reportedly associated with anorexia nervosa ( AN ). We genotyped the c.385C>A SNP (rs324420) in 762 lifetime AN and 605 control participants in Japan. There were significant differences in the genotype and allele frequencies of c.385C>A between the AN and control groups. The minor 385A allele was less frequent in the AN participants than in the controls (allele‐wise, odds ratio = 0.799, 95% confidence interval [ CI ] 0.653–0.976, P = 0.028). When the cases were subdivided into lifetime restricting subtype AN and AN with a history of binge eating or purging, only the restricting AN group exhibited a significant association (allele‐wise, odds ratio = 0.717, 95% CI 0.557–0.922, P = 0.0094). Our results suggest that having the minor 385A allele of the FAAH gene may be protective against AN , especially restricting AN . This finding supports the possible role of the endocannabinoid system in susceptibility to AN .