Open AccessMaternal genetic markers for risk of celiac disease and their potential association with neural tube defects in offspring
Author(s) -
Hoang Thanh T.,
Lei Yunping,
Mitchell Laura E.,
Sharma Shreela V.,
Swartz Michael D.,
Waller D. Kim,
Finnell Richard H.,
Benjamin Renata H.,
Browne Marilyn L.,
Canfield Mark A.,
Lupo Philip J.,
McKenzie Paige,
Shaw Gary M.,
Agopian A. J.
Publication year - 2019
Publication title -
molecular genetics and genomic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.765
H-Index - 29
ISSN - 2324-9269
DOI - 10.1002/mgg3.688
Subject(s) - offspring , neural tube , medicine , disease , human leukocyte antigen , case control study , pregnancy , logistic regression , genotype , immunology , genetics , biology , antigen , gene , embryo
Background We examined the association between the maternal genotype for celiac disease‐associated variants and risk of neural tube defects (NTDs). Methods We conducted a case–control study, using data from the National Birth Defects Prevention Study. We evaluated 667 cases (women with an offspring with NTD) and 743 controls (women with an offspring without a birth defect). We classified women as having low, intermediate, or high risk of celiac disease based on human leukocyte antigen (HLA) variants. We used logistic regression to assess the relationship between HLA celiac risk group (low, intermediate, high) and risk of NTDs. Fifteen non‐HLA variants (identified from genome‐wide association studies of celiac disease) were individually evaluated and modeled additively. Results There was no association between HLA celiac risk group and NTDs (intermediate vs. low risk: aOR, 1.0; 95% CI, 0.8–1.3; high vs. low risk: aOR, 0.8; 95% CI, 0.5–1.3). Of the fifteen non‐HLA variants, we observed five significant associations after accounting for multiple comparisons. Three negative associations were observed with rs10903122, rs13314993, rs13151961 (aOR range: 0.69–0.81), and two positive associations were observed with rs13003464 and rs11221332 (aOR range: 1.27–1.73). Conclusion If confirmed, our results suggest that the maternal variants related to celiac disease may be involved in the risk of NTDs.