Open AccessThe association of nucleotide‐binding oligomerization domain 2 gene polymorphisms with the risk of asthma in the Chinese Han population
Author(s) -
Cai Xulong,
Xu Qiaolan,
Zhou Chenrong,
Zhou Li,
Dai Weihua,
Ji Guanchi
Publication year - 2019
Publication title -
molecular genetics and genomic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.765
H-Index - 29
ISSN - 2324-9269
DOI - 10.1002/mgg3.675
Subject(s) - asthma , single nucleotide polymorphism , nod , snp , pathogenesis , medicine , genotyping , immunology , allele , genotype , gene , genetics , biology
Background Genetic background is one of the important risk factors for development of asthma. The nucleotide‐binding oligomerization domain 2 ( NOD 2 ) has been involved in the pathogenesis of asthma. The purpose of this study was to explore the relationship between NOD 2 gene polymorphisms and asthma susceptibility in the Chinese Han population. Methods Children with asthma ( n = 309) and Healthy children ( n = 163) were recruited from Yancheng Third People's Hospital, Yancheng, China, between January 2016 and December 2017. The NOD 2 gene polymorphisms were measured by the Snapshot SNP genotyping assays. Genotyping was performed for 4 tag SNP s of NOD 2 . Serum IFN ‐β levels were measured by ELISA . Results The serum IFN ‐β levels were significantly lower in Asthmatic children than those in the controls ( p < 0.001). Low levels of IFN ‐β may be related to the susceptibility to severe asthma. The rs3135499 C allele was associated with a significantly increased risk of asthma as compared with the rs3135499 A allele. Conclusion The rs3135499 polymorphism of NOD 2 gene and IFN ‐β may play a role in the pathogenesis of asthma.