Open AccessAssociations of intercellular adhesion molecule‐1 rs5498 polymorphism with ischemic stroke: A meta‐analysis
Author(s) -
Gao Hua,
Zhang Xinhua
Publication year - 2019
Publication title -
molecular genetics and genomic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.765
H-Index - 29
ISSN - 2324-9269
DOI - 10.1002/mgg3.643
Subject(s) - odds ratio , meta analysis , confidence interval , medicine , subgroup analysis , allele , gastroenterology , polymorphism (computer science) , intercellular adhesion molecule 1 , ischemic stroke , genetics , biology , ischemia , gene , inflammation
Background Recently, associations between intercellular adhesion molecule‐1 ( ICAM‐1 ) rs5498 polymorphism and ischemic stroke (IS) were investigated by several pilot studies, but with inconsistent results. In this study, a meta‐analysis was performed to better assess the relationship between ICAM‐1 rs5498 polymorphism and IS. Methods PubMed, Medline, Embase, and CNKI were searched for eligible studies. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) to evaluate associations between ICAM‐1 rs5498 polymorphism and IS. Results Totally 16 studies with 2,596 cases and 11,800 controls were analyzed. A significant association with IS was observed for rs5498 polymorphism in GG versus AA + AG (recessive model, p = 0.009, OR = 1.62, 95% CI 1.13–2.32, I 2 = 76%) in overall population. Further subgroup analyses showed that rs5498 polymorphism was significantly associated with IS in Caucasians in AA versus AG + GG (dominant model, p = 0.03, OR = 0.52, 95% CI 0.29–0.95, I 2 = 72%), GG versus AA + AG (recessive model, p < 0.0001, OR = 2.98, 95% CI 2.05–4.31, I 2 = 19%), and A versus G (allele model, p = 0.005, OR = 0.50, 95% CI 0.31–0.81, I 2 = 81%). However, no any positive findings were detected for Asians. Conclusions Our findings indicated that rs5498 polymorphism was significantly associated with individual susceptibility to IS in Caucasians, but not in Asians.