Open AccessGenetics of IL6 polymorphisms: Case–control study of the risk of endometrial cancer
Author(s) -
Cai Junhong,
Cui Kaiying,
Niu Fanglin,
Jin Tianbo,
Huang Sizhe,
Zhang Ying,
Bao Shan
Publication year - 2019
Publication title -
molecular genetics and genomic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.765
H-Index - 29
ISSN - 2324-9269
DOI - 10.1002/mgg3.600
Subject(s) - endometrial cancer , odds ratio , oncology , medicine , logistic regression , case control study , single nucleotide polymorphism , confidence interval , snp , genotype , gynecology , genetic model , gene , genetics , cancer , biology
Background Endometrial cancer is the most common gynaecological malignancy. Cytokines gene may be important in endometrial cancer development. This study sought to investigate whether the IL4 , IL6 two gene genetic variants were associated with susceptibility to endometrial cancer (EC) in Hainan Chinese Han women by a hospital‐based study. Methods The genetic polymorphisms for IL4 and IL6 were analyzed by Agena MassARRAY method. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression. Results We observed a significant increase in risk of endometrial cancer of rs1524107 ( IL6 ) (T/C, OR = 1.61, 95% CI = 1.09–2.37, p = 1.55 × 10 −2 ), rs2066992 ( IL 6 ) (OR = 3.09, 95% CI = 2.11–4.53, p = 3.13 × 10 −9 ). However, for IL4 gene, no associations emerged the SNP and EC risk. Conclusion This study demonstrated that IL6 gene polymorphisms are significantly associated with increased EC susceptibility in Hainan Chinese Han women.