Open AccessAssociation between single nucleotide polymorphism (rs4252424) in TRPV5 calcium channel gene and lead poisoning in Chinese workers
Author(s) -
Liu Jiting,
Zhang Li,
Feng Lixia,
Xu Ming,
Gao Yue,
Zhou Peng,
Yu Zhengmin,
Zhu Baoli,
An Yan,
Zhang Hengdong
Publication year - 2019
Publication title -
molecular genetics and genomic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.765
H-Index - 29
ISSN - 2324-9269
DOI - 10.1002/mgg3.562
Subject(s) - single nucleotide polymorphism , genotyping , lead poisoning , snp , genotype , snp genotyping , blood lead level , genetics , taqman , polymorphism (computer science) , biology , lead exposure , medicine , gene , real time polymerase chain reaction , cats , psychiatry
Background Lead (Pb) is broadly used in various industries and causes irreversible damage to human tissues, organs, and systems. Studies have revealed that lead exerts toxic effects via interfering with calcium channel. Methods In the present study, we investigated whether single nucleotide polymorphisms (SNPs) in TRPV5 , a calcium channel‐related gene, were associated with lead exposure susceptibility. By using TaqMan SNP genotyping, we performed genotyping of eight TRPV5 tag‐SNPs in 1,130 lead‐exposed Chinese workers with similar lead exposure level. Results Single nucleotide polymorphism rs4252424 was significantly associated with lead susceptibility, measured by blood lead level (BLL) ( β = −0.069, p linear = 0.029). However, there was no significant association between any other seven SNPs and BLL. The further expression Quantitative Trait Loci displayed that CC genotype of rs4252424 is significant associated with higher BLL than CT ( p < 0.0001). Conclusion We conclude that SNP rs4252424 has the potential to evaluate lead susceptibility in the Chinese occupational population, and further enhance lead exposure prevention and intervention.