Open AccessThe 6q25.1 rs2046210 polymorphism is associated with an elevated susceptibility to breast cancer: A meta‐analysis of 261,703 subjects
Author(s) -
Jin Tiefeng,
Zhang Wenting,
Zhou Zhenfeng
Publication year - 2019
Publication title -
molecular genetics and genomic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.765
H-Index - 29
ISSN - 2324-9269
DOI - 10.1002/mgg3.553
Subject(s) - odds ratio , meta analysis , confidence interval , breast cancer , medicine , gastroenterology , allele , subgroup analysis , web of science , genotype , polymorphism (computer science) , oncology , genetics , cancer , biology , gene
Abstract Background Several genome‐wide association studies already explored the associations between 6q25.1 rs2046210 polymorphism and breast cancer (BC), but the results of these studies were not consistent. Thus, we conducted a meta‐analysis of relevant studies to better analyze the effects of rs2046210 polymorphism on individual susceptibility to BC. Methods PubMed, Web of Science, and Embase were searched for eligible studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results Totally 21 studies with 261,703 subjects were analyzed. A significant association with BC was observed for the rs2046210 polymorphism in GG versus GA +AA (dominant comparison, p < 0.0001, OR = 0.78, 95% CI 0.73–0.83), AA versus GG + GA (recessive comparison, p < 0.0001, OR = 1.21, 95% CI 1.18–1.24), GA versus GG + AA (overdominant comparison, p < 0.0001, OR = 1.12, 95% CI 1.08–1.16), and G versus A (allele comparison, p < 0.0001, OR = 0.86, 95% CI 0.82–0.89). Further subgroup analyses yielded similar positive results in both Asians and Caucasians. Conclusion In summary, our findings suggested that the rs2046210 polymorphism may serve as a potential genetic biomarker of BC in both Asians and Caucasians.