Open AccessAssociation study in three different populations between the GPR 88 gene and major psychoses
Author(s) -
Del Zompo Maria,
Deleuze JeanFrançois,
Chillotti Caterina,
Cousin Emmanuelle,
Niehaus Dana,
Ebstein Richard P.,
Ardau Raffaella,
Macé Sandrine,
Warnich Louise,
Mujahed Mustafa,
Severino Giovanni,
Dib Colette,
Jordaan Esme,
Murad Ibrahim,
Soubigou Stéphane,
Koen Liezl,
Bannoura Issam,
Rocher Corinne,
Laurent Claudine,
Derock Murielle,
Faucon Biguet Nicole,
Mallet Jacques,
Meloni Rolando
Publication year - 2014
Publication title -
molecular genetics and genomic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.765
H-Index - 29
ISSN - 2324-9269
DOI - 10.1002/mgg3.54
Subject(s) - population , medicine , schizophrenia (object oriented programming) , candidate gene , psychiatry , genetics , biology , gene , environmental health
GPR 88 , coding for a G protein‐coupled orphan receptor that is highly represented in the striatum, is a strong functional candidate gene for neuropsychiatric disorders and is located at 1p22‐p21, a chromosomal region that we have previously linked to bipolar disorder ( BD ) in the Sardinian population. In order to ascertain the relevance of GPR 88 as a risk factor for psychiatric diseases, we performed a genetic association analysis between GPR 88 and BD in a sample of triads (patient and both parents) recruited in the Sardinian and the Palestinian population as well as between GPR 88 and schizophrenia ( SZ ) in triads from the Xhosa population in South Africa. We found a positive association between GPR 88 and BD in the Sardinian and Palestinian triads. Moreover, we found a positive association between GPR 88 and SZ in triads from the Xhosa population in South Africa. When these results were corrected for multiple testing, the association between GPR 88 and BD was maintained in the Palestinian population. Thus, these results suggest that GPR 88 deserves consideration as a candidate gene for psychiatric diseases and requires to be further investigated in other populations.