Open AccessMMP ‐14 single‐nucleotide polymorphisms are related to steroid‐induced osteonecrosis of the femoral head in the population of northern China
Author(s) -
Qi Yuxin,
Wang Jiaqi,
Sun Mingqi,
Ma Chao,
Jin Tianbo,
Liu Yuan,
Cao Yuju,
Wang Jianzhong
Publication year - 2019
Publication title -
molecular genetics and genomic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.765
H-Index - 29
ISSN - 2324-9269
DOI - 10.1002/mgg3.519
Subject(s) - femoral head , single nucleotide polymorphism , haplotype , snp , odds ratio , genotype , medicine , confidence interval , population , genetic model , matrix metalloproteinase , bioinformatics , genetics , oncology , pathology , endocrinology , biology , gene , surgery , environmental health
Background Osteonecrosis of the femoral head ( ONFH ) is a refractory disease which frequently occurs in young and middle‐aged people. Recent studies indicated that MMP ‐14 played an important role in the development of chondrocytes, metabolism of osteoblasts as well as fate decision of hypertrophic chondrocytes. The aim of this study was to investigate the association between polymorphisms of MMP ‐14 and steroid‐induced osteonecrosis of the femoral head in the Chinese population. Methods We selected 7 SNP s (rs3751488, rs1003349, rs1042703, rs2236302, rs1042704, rs2236303, and rs2236304) on gene MMP ‐14 . Odds ratios ( OR s) and 95% confidence intervals ( CI s) were estimated using the chi‐squared test, genetic model analysis, haplotype analysis, and stratification analysis. Results We discovered that the genotype “G/G” of rs2236302 was associated with ONFH risk in the MMP ‐14 in the codominant model ( OR = 8.62, 95% CI = 1.07–69.46, p = 0.038) and recessive model ( OR = 8.86, 95% CI = 1.10–71.31, p = 0.013). Conclusions We have confirmed that the susceptive SNP s (rs2236302) of MMP ‐14 from the MMP s/ TIMP s system exhibit a significant association with increased risk of steroid‐induced ONFH in the population of northern China.