Open AccessAssociation of low‐density lipoprotein receptor‐related protein 1 rs11613352 and angiopoietin‐like 3 rs2131925 with hypertension in men—the Tampere adult population cardiovascular risk study
Author(s) -
Kunnas Tarja,
Solakivi Tiina,
Nikkari Seppo T.
Publication year - 2018
Publication title -
molecular genetics and genomic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.765
H-Index - 29
ISSN - 2324-9269
DOI - 10.1002/mgg3.450
Subject(s) - genotype , medicine , endocrinology , allele , ldl receptor , population , lipoprotein , biology , cholesterol , genetics , gene , environmental health
Background We examined the association of three known genome‐wide association study loci for blood lipids that have lead traits for triglycerides with hypertension in the Tampere adult population cardiovascular risk study. Methods A Finnish cohort of 190 men with diagnosed hypertension and 279 controls were analyzed. Samples were genotyped for low‐density lipoprotein receptor‐related protein 1 rs11613352 (C>T), angiopoietin‐like 3 rs2131925 (T>G), and fatty acid desaturase 1 rs174546 (C>T) polymorphisms using competitive allele‐specific polymerase chain reaction technique. Results At the age of 50, subjects with low‐density lipoprotein receptor‐related protein 1 rs11613352 (C>T) minor genotype TT had significantly more hypertension than those with the C allele ( OR 5.17, CI 2.03–12.74, p < 0.001). Subjects with angiopoietin‐like 3 rs2131925 (T>G) T allele had more hypertension than those with the minor genotype GG ( OR 5.02, CI 1.40–17.98, p = 0.013). Fatty acid desaturase 1 rs174546 (C>T) did not associate with hypertension. Conclusion Association of low‐density lipoprotein receptor‐related protein 1 rs11613352 and angiopoietin‐like 3 rs2131925 with hypertension might imply a direct effect at the artery wall.