Open AccessAssessing risk for Mendelian disorders in a Bronx population
Author(s) -
diSibio Guy,
Upadhyay Kinnari,
Meyer Philip,
Oddoux Carole,
Ostrer Harry
Publication year - 2017
Publication title -
molecular genetics and genomic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.765
H-Index - 29
ISSN - 2324-9269
DOI - 10.1002/mgg3.307
Subject(s) - mendelian inheritance , genetics , exome sequencing , medical genetics , biology , ethnic group , exome , population , medicine , mutation , gene , environmental health , sociology , anthropology
Background To identify variants likely responsible for Mendelian disorders among the three major ethnic groups in the Bronx that might be useful to include in genetic screening panels or whole exome sequencing filters and to estimate their likely prevalence in these populations. Methods Variants from a high‐density oligonucleotide screen of 192 members from each of the three ethnic‐national populations (African Americans, Puerto Ricans, and Dominicans) were evaluated for overlap with next generation sequencing data. Variants were curated manually for clinical validity and utility using the American College of Medical Genetics ( ACMG ) scoring system. Additional variants were identified through literature review. Results A panel of 75 variants displaying autosomal dominant, autosomal recessive, autosomal recessive/digenic recessive, X‐linked recessive, and X‐linked dominant inheritance patterns representing 39 Mendelian disorders were identified among these populations. Conclusion Screening for a broader range of disorders could offer the benefits of early or presymptomatic diagnosis and reproductive choice.