Open AccessGene expression of oxidative stress markers and lung function: A CARDIA lung study
Author(s) -
Ramasubramanian Ramya,
Kalhan Ravi,
Jacobs David R.,
Washko George R.,
Hou Lifang,
Gross Myron D.,
Guan Weihua,
Thyagarajan Bharat
Publication year - 2021
Publication title -
molecular genetics and genomic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.765
H-Index - 29
ISSN - 2324-9269
DOI - 10.1002/mgg3.1832
Subject(s) - medicine , quartile , vital capacity , spirometry , oxidative stress , lung , cardiology , pulmonary function testing , rotterdam study , gastroenterology , lung function , prospective cohort study , diffusing capacity , confidence interval , asthma
Background Circulating markers of oxidative stress have been associated with lower lung function. Our objective was to study the association of gene expression levels of oxidative stress pathway genes ( ALOX12 , ALOX15 , ARG2 , GSTT1 , LPO , MPO , NDUFB3 , PLA2G7 , and SOD3) and lung function forced expiratory volume in one second (FEV 1 ), forced vital capacity (FVC) in Coronary Artery Risk Development in Young Adults study. Methods Lung function was measured using spirometry and the Nanostring platform was used to estimate gene expression levels. Linear regression models were used to study association of lung function measured at year 30, 10‐year decline in lung function and gene expression after adjustment for center, smoking, and BMI, measured at year 25. Results The 10‐year decline of FEV 1 was faster in highest NDUFB3 quartile compared to the lowest (difference = −2.09%; p = 0.001) after adjustment for multiple comparisons. The 10‐year decline in FEV 1 and FVC was nominally slower in highest versus lowest quartile of PLA2G7 (difference = 1.14%; p = 0.02, and difference = 1.06%; p = 0.005, respectively). The other genes in the study were not associated with FEV 1 or FVC. Conclusion Higher gene expression levels in oxidative stress pathway genes are associated with faster 10‐year FEV 1 decline.