Open AccessThe impact of CYP19A1 variants and haplotypes on breast cancer risk, clinicopathological features and prognosis
Author(s) -
Alwan Ahmad Mohammed,
Afzaljavan Fahimeh,
Tavakol Afshari Jalil,
Homaei Shandiz Fatemeh,
Barati Bagherabad Matineh,
Vahednia Elham,
Kheradmand Nahid,
Pasdar Alireza
Publication year - 2021
Publication title -
molecular genetics and genomic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.765
H-Index - 29
ISSN - 2324-9269
DOI - 10.1002/mgg3.1705
Subject(s) - breast cancer , haplotype , linkage disequilibrium , allele , oncology , genetic association , medicine , locus (genetics) , disease , cancer , biology , single nucleotide polymorphism , genetics , genotype , gene
Abstract Background Different genetic variants in hormone‐regulating pathways have been identified to influence the risk of breast cancer. This study aimed to evaluate the association of CYP19A1 rs10046 and rs700519 polymorphisms with the risk, clinicopathological factors and prognosis of breast cancer. Methods In a case‐control study, rs10046 and rs 700519 polymorphisms were genotyped using ARMS‐PCR and high‐resolution melting (HRM), respectively, in a total of 702 females. Statistical analysis and evaluation of haplotypes and linkage disequilibrium were performed using SPSS v16, PHASE and 2LD. Results Although no association of rs700519 with breast cancer was observed, rs10046 in different genetic models as well as C‐C/C‐T and C‐C/C‐C diplotypes, revealed the association with the risk of breast cancer ( p < 0.05). Moreover, the rs700519 ‐C allele was shown to be associated with longer overall survival. In contrast, the T‐T haplotype conferred s a shorter overall survival. rs700519 ‐C allele was also significantly associated with menarche age. Conclusion Based on the identified independent association between CYP19A1 diplotypes and rs700519 ‐C allele with the risk and prognosis of the disease, the gene region and its genetic variants may have a diagnostic and prognostic role in breast cancer development. Further confirmation using other variants in this locus can validate these findings.