Open AccessEvaluation of genetic association of neurodevelopment and neuroimmunological genes with antipsychotic treatment response in schizophrenia in Indian populations
Author(s) -
Jajodia Ajay,
Kaur Harpreet,
Kumari Kalpana,
Kanojia Neha,
Gupta Meenal,
Baghel Ruchi,
Sood Mamta,
Jain Sanjeev,
Chadda Rakesh K.,
Kukreti Ritushree
Publication year - 2016
Publication title -
molecular genetics and genomic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.765
H-Index - 29
ISSN - 2324-9269
DOI - 10.1002/mgg3.169
Subject(s) - antipsychotic , schizophrenia (object oriented programming) , medicine , psychiatry , genetic association , psychosis , gene , genetics , biology , genotype , single nucleotide polymorphism
Neurodevelopmental and neuroimmunological genes critically regulate antipsychotic treatment outcome. We report genetic associations of antipsychotic response in 742 schizophrenia patients from Indian populations of Indo‐European and Dravidian ancestry, segregated by disease severity. Meta‐analysis comparing the two populations identified CCL 2 [rs4795893: OR (95% CI ) = 1.79 (1.27–2.52), P = 7.62 × 10 −4 ; rs4586: OR (95% CI ) = 1.74 (1.24–2.43), P = 1.13 × 10 −3 ] and GRIA 4 [rs2513265: OR (95% CI ) = 0.53 (0.36–0.78), P = 1.44 × 10 −3 ] in low severity group; and, ADCY 2 [rs1544938: OR (95% CI ) = 0.36 (0.19–0.65), P = 7.68 × 10 −4 ] and NRG 1 [rs13250975, OR (95% CI ) = 0.42 (0.23–0.79), P = 6.81 × 10 −3 ; rs17716295, OR (95% CI ) = 1.78 (1.15–2.75), P = 8.71 × 10 −3 ] in high severity group, with incomplete response toward antipsychotics. To our knowledge, this is the first study to identify genetic polymorphisms associated with the efficacy of antipsychotic treatment of schizophrenia patients from two major India populations.