Open AccessClinical heterogeneity and intrafamilial variability of Joubert syndrome in two siblings with CPLANE1 variants
Author(s) -
Zhang Xiujuan,
Shen Yue,
Li Ping,
Cai Ruikun,
Lu Chao,
Li Qian,
Chen Cuixia,
Yu Yufei,
Cheng Tingting,
Wang Xian,
Luo Minna,
Cao Muqing,
Cao Zongfu,
Ma Xu
Publication year - 2021
Publication title -
molecular genetics and genomic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.765
H-Index - 29
ISSN - 2324-9269
DOI - 10.1002/mgg3.1682
Subject(s) - joubert syndrome , genetics , frameshift mutation , missense mutation , genetic heterogeneity , sibling , phenotype , biology , genotype , gene , psychology , developmental psychology
Background Joubert syndrome (JBTS) is a rare genetic disorder that is characterized by midbrain‐hindbrain malformations. Multiple variants in genes that affect ciliary function contribute to the genetic and clinical heterogeneity of JBTS and its subtypes. However, the correlation between genotype and phenotype has not been elucidated due to the limited number of patients available. Methods In this study, we observed different clinical features in two siblings from the same family. The older sibling was classified as a pure JBTS patient, whereas her younger sibling displayed oral‐facial‐digital defects and was therefore classified as an oral‐facial‐digital syndrome type VI (OFD VI) patient. Next, we performed human genetic tests to identify the potential pathogenic variants in the two siblings. Results Genetic sequencing indicated that both siblings harbored compound heterozygous variants of a missense variant (c.1067C>T, p.S356F) and a frameshift variant (c.8377_8378del, p.E2793Lfs*24) in CPLANE1 (NM_023073.3). Conclusion This study reports that two novel CPLANE1 variants are associated with the occurrence of JBTS and OFD VI. These results help elucidate the intrafamilial phenotypic variability associated with CPLANE1 variants.