Open AccessAssociation of the STAT4 , CDKN1A , and IRF5 variants with risk of lupus nephritis and renal biopsy classification in patients in Vietnam
Author(s) -
Nghiem Trung Dung,
Do Gia Tuyen,
Luong Long Hoang,
Nguyen Quy Linh,
Dang Ha Viet,
Viet Anh Nguyen,
Nguyen Thuy Thu,
Tran Van Khanh,
Ta Thanh Van,
Tran Thinh Huy
Publication year - 2021
Publication title -
molecular genetics and genomic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.765
H-Index - 29
ISSN - 2324-9269
DOI - 10.1002/mgg3.1648
Subject(s) - lupus nephritis , irf5 , medicine , single nucleotide polymorphism , population , immunology , gastroenterology , genotype , disease , biology , gene , genetics , immune system , interferon regulatory factors , environmental health , innate immune system
Background Lupus nephritis is a common complication of systemic lupus erythematosus (SLE, OMIM #15200) in the Asian population and a main contributor to mortality and morbidity. In this study, we evaluate the variants on three genes STAT4 , CDKN1A , and IRF5 and their association with lupus nephritis. Method One hundred fifty‐two SLE patients with confirmed lupus nephritis (through biopsy) and 76 healthy controls were recruited. Genotyping of SNPs on three gene STAT4 , CDKN1A , and IRF5 , phenotypic, and laboratory assessment were performed; renal biopsy and classification were carried out for the patient group. Results Carriers of rs7582694 C alleles on STAT4 have higher risk of lupus nephritis (OR 2.0; 95% CI [1.14, 3.19]; p = 0.015), at higher risk of hematuria and higher serum level of dsDNA antibodies compared to controls ( p < 0.05) and were more likely to have nephrotic histopathology grading of class III or higher. No association was observed for CDKN1A ; and no variation was observed for the IRF5 gene in both the study and control group. Conclusion This study investigates the relationship between STAT4 , CDKN1A , and IRF5 gene and SLE in a Vietnamese patient population. Patients with the C allele ( STAT4 ) in rs7582694 were associated with a more severe disease phenotype.