Open AccessHigh frequency of the risk allele of rs4132601 and rs11978267 from the IKZF1 gene in indigenous Mexican population
Author(s) -
GutiérrezFranco Jorge,
AyónPérez Miriam Fabiola,
DuránAvelar Ma. de Jesús,
VibancoPérez Norberto,
SánchezJasso Diego Eduardo,
BañuelosAguayo Dulce Guadalupe,
SánchezMeza Jaime,
PimentelGutiérrez Helia Judith,
ZambranoZaragoza José Francisco,
AgrazCibrián Juan Manuel,
VázquezReyes Alejandro
Publication year - 2021
Publication title -
molecular genetics and genomic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.765
H-Index - 29
ISSN - 2324-9269
DOI - 10.1002/mgg3.1589
Subject(s) - allele , genotype , allele frequency , population , genetics , indigenous , polymorphism (computer science) , biology , genotype frequency , medicine , gene , environmental health , ecology
Abstract Background IKZF1 is a relevant gene associated with the pathogenesis of acute lymphoblastic leukemia, and the rs 4132601 (T>G) and rs 11978267 (A>G) polymorphisms have been associated with the development of this disease in several populations. The aim of this study was to determine the allelic and genotypic frequencies of the rs 4132601 and rs 11978267 polymorphisms in two indigenous Mexican groups (Cora and Huichol) and Mestizo populations from Nayarit, Mexico, and compare them with the frequencies of both polymorphisms in other populations of the world. Methods One hundred, 116, and 100 subjects from the Mestizo, Huichol, and Cora populations, respectively, all of them residents of the state of Nayarit, Mexico, were analyzed. The frequencies of rs4132601 and rs11978267 were determined by allelic discrimination using TaqMan assays. Results The allelic frequencies of rs4132601 were as follows: Mestizo group T = 0.74, G = 0.26; Cora T = 0.745, G = 0.255; and Huichol T = 0.47, G = 0.53. In the case of the rs11978267 polymorphism, the allelic frequencies were Mestizo A = 0.745, G = 0.255; Cora A = 0.735, G = 0.265; and Huichol A = 0.457, G = 0.543. For each population, both polymorphisms were in Hardy–Weinberg equilibrium. Conclusion The Huichol population from Nayarit presented the highest frequencies of the risk allele reported to date in the whole world for both rs 4132601 and rs 11978267 polymorphisms.