Open AccessGain‐of‐function mutation Met136Val in SCN8A may not be a common cause of trigeminal neuralgia
Author(s) -
Sekula Raymond F.,
Deeley Kathleen,
Denwood Hayley,
Vieira Alexandre R.
Publication year - 2021
Publication title -
molecular genetics and genomic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.765
H-Index - 29
ISSN - 2324-9269
DOI - 10.1002/mgg3.1587
Subject(s) - trigeminal neuralgia , medicine , mutation , dermatology , genetics , anesthesia , biology , gene
Background The Met136Val mutation in SCN8A was described in a case of trigeminal neuralgia but no frequency among affected individuals was provided. Methods Direct sequencing of 123 individuals diagnosed with classic trigeminal neuralgia was performed aimed to detect the Met136Val change. Results No cases of classical trigeminal neuralgia studied had the Met136Val mutation in SCN8A . Conclusion Met136Val mutation in SCN8A is not a frequent cause of classical trigeminal neuralgia.