Open AccessMutant COMP shapes growth and development of skull and facial structures in mice and humans
Author(s) -
Burger Alexander,
Roosenboom Jasmien,
Hossain Mohammad,
Weinberg Seth M.,
Hecht Jacqueline T.,
Posey Karen L.
Publication year - 2020
Publication title -
molecular genetics and genomic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.765
H-Index - 29
ISSN - 2324-9269
DOI - 10.1002/mgg3.1251
Subject(s) - endochondral ossification , intramembranous ossification , cartilage oligomeric matrix protein , skull , anatomy , cartilage , craniofacial , biology , pathology , medicine , genetics , osteoarthritis , alternative medicine
Background Cartilage oligomeric matrix protein (COMP) is an important extracellular matrix protein primarily functioning in the musculoskeletal tissues and especially endochondral bone growth. Mutations in COMP cause the skeletal dysplasia pseudoachondroplasia (PSACH) that is characterized by short limbs and fingers, joint laxity, and abnormalities but a striking lack of skull and facial abnormalities. Methods This study examined both mice and humans to determine how mutant‐COMP affects face and skull growth. Results Mutant COMP (MT‐COMP) mice were phenotypically distinct. Snout length and skull height were diminished in MT‐COMP mouse and the face more closely resembled younger controls. Three‐dimensional facial measurements of PSACH faces showed widely spaced eyes, reduced lower facial height, and decreased nasal protrusion, which correlated with a more juvenile appearing face. Neither MT‐COMP mice nor PSACH individuals show midface hypoplasia usually associated with abnormal endochondral bone growth. MT‐COMP mice do show delayed endochondral and membranous skull ossification that normalizes with age. Conclusion Therefore, mutant‐COMP affects both endochondral and intramembranous bones of the skull resulting in a reduction of the nose and lower facial height in mice and humans, in addition to its well‐defined role in the growth plate chondrocytes.