Open AccessGenetic contributions to the etiology of anorexia nervosa: New perspectives in molecular diagnosis and treatment
Author(s) -
Paolacci Stefano,
Kiani Aysha Karim,
Manara Elena,
Beccari Tommaso,
Ceccarini Maria Rachele,
Stuppia Liborio,
Chiurazzi Pietro,
Dalla Ragione Laura,
Bertelli Matteo
Publication year - 2020
Publication title -
molecular genetics and genomic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.765
H-Index - 29
ISSN - 2324-9269
DOI - 10.1002/mgg3.1244
Subject(s) - anorexia nervosa , etiology , disease , anxiety , medicine , anorexia , psychiatry , eating disorders , psychology , bioinformatics , biology
Abstract Background Anorexia nervosa is a multifactorial eating disorder that manifests with self‐starvation, extreme anxiety, hyperactivity, and amenorrhea. Long‐term effects include organ failure, disability, and in extreme cases, even death. Methods Through a literature search, here we summarize what is known about the molecular etiology of anorexia nervosa and propose genetic testing for this condition. Results Anorexia nervosa often has a familial background and shows strong heritability. Various genetic studies along with genome‐wide association studies have identified several genetic loci involved in molecular pathways that might lead to anorexia. Conclusion Anorexia nervosa is an eating disorder with a strong genetic component that contributes to its etiology. Various genetic approaches might help in the molecular diagnosis of this disease and in devising novel therapeutic options.