Open AccessRole of Helicobacter pylori infection in the manifestation of old age‐related diseases
Author(s) -
Zendehdel Abolfazl,
Roham Maryam
Publication year - 2020
Publication title -
molecular genetics and genomic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.765
H-Index - 29
ISSN - 2324-9269
DOI - 10.1002/mgg3.1157
Subject(s) - disease , medicine , helicobacter pylori , pathogenesis , cancer , helicobacter pylori infection , risk factor , osteoporosis , immunology , bioinformatics , intensive care medicine , biology
Helicobacter pylori is one of the most prevalent infection worldwide. It affects individuals of different age groups. Elderly people tend to resist eradication treatment and worsening of infection can lead to several gastric and non‐gastric pathologies. Aging‐associated cellular and molecular alteration can increase the risk of other pathologies such as osteoporosis, Alzheimer's disease, Parkinson's disease, respiratory and renal dysfunction, and cancer in geriatric patients, more than other age groups. This review article highlights some of the most common old age diseases and the role of H. pylori infection as a risk factor to worsen the conditions, presented by the molecular evidences of these associations. These studies can help clinicians to understand the underlying pathogenesis of the disease and identify high‐risk patients, aiding clearer diagnosis and treatment.