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Growth factor second messenger systems: Oncogenes and the heterotrimeric GTP‐;binding protein connection
Author(s) -
Crouch Michael F.,
Hendry Ian A.
Publication year - 1993
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.2610130105
Subject(s) - heterotrimeric g protein , signal transduction , biology , tyrosine kinase , second messenger system , g protein , microbiology and biotechnology , receptor tyrosine kinase , genetics
We feel that there is now compelling evidence that the GTP-binding proteins play more than just a coordinating role in the actions of both tyrosine kinase and nontyrosine kinase receptor signal transduction. These similarities appear to represent just a small component of the convergence in the signaling pathways for structurally dissimilar receptor subsets. Future years will see further understanding of the intricacies of these G-protein-proto-oncogene interactions, and the extension into the potential role in growth factor action played by the expanding number of known members of this G-protein family.