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Drugs acting on the intracellular signalling system
Author(s) -
Nomura Yasuyuki,
Kitamura Yoshihisa,
Tohda Michihisa,
Tokumitsu Yukiko
Publication year - 1993
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.2610130102
Subject(s) - second messenger system , signalling , intracellular , kinase , extracellular , phosphatase , microbiology and biotechnology , signal transduction , cell signaling , signalling pathways , biology , receptor , phosphorylation , biochemistry
Cellular response to extracellular messages is a basic process to maintain and to support cell life. Several signalling molecules important as sites of therapeutic drug action are involved in the response. Recent studies on life sciences have elucidated molecular properties of intracellular signalling factors and mechanisms of cascading. Novel drugs acting on signalling molecules and possessing new sites and mechanisms of action have been found. This article summarizes the properties (subtypes, structures, functions) of signalling factors (receptors, ion channels, GTP binding proteins, second messenger-generating enzymes, second messenger-metabolizing enzymes, second messengers protein kinases, protein phosphatases) and lists in Tables A-H drugs that act on signalling molecules and which should find clinical use.