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Use of microorganisms for the study of drug metabolism: An update
Author(s) -
Clark Alice M.,
Hufford Charles D.
Publication year - 1991
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.2610110503
Subject(s) - pharmacognosy , pharmacy , library science , pharmaceutical technology , medicine , chemistry , computer science , family medicine , biochemistry , chromatography , biological activity , in vitro
The use of microorganisms as tools in the study of drug metabolism appears to be gaining popularity. The selected examples cited here provide additional evidence of the utility of these systems as alternative in vitro models for studying drug metabolism in humans. However, as was noted earlier, this model, nor any other in vitro model system could ever replace animals in biomedical research. However, it is apparent from the numerous examples cited here and in the previous review of this area that microorganisms are a reliable, reproducible alternative to small animals as predictive models in drug metabolism studies. The continuing development of techniques that reduce the use of animals in research is encouraged and this procedure appears to be gaining more widespread acceptance for such use.