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How selective are clinical CDK4/6 inhibitors?
Author(s) -
Hendrychová Denisa,
Jorda Radek,
Kryštof Vladimír
Publication year - 2021
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.21769
Subject(s) - palbociclib , context (archaeology) , repurposing , drug repositioning , clinical trial , cyclin dependent kinase , pharmacology , kinase , autophagy , cancer , drug discovery , biology , medicine , drug , cell cycle , breast cancer , bioinformatics , metastatic breast cancer , apoptosis , microbiology and biotechnology , paleontology , ecology , biochemistry
Pharmacological inhibition of cyclin‐dependent kinase 4/6 (CDK4/6) has emerged as an efficient approach for treating breast cancer, and its clinical potential is expanding to other cancers. CDK4/6 inhibitors were originally believed to act by arresting proliferation in the G1 phase, but it is gradually becoming clear that the cellular response to these compounds is far more complex than this. Multiple context‐dependent mechanisms of action are emerging, involving modulation of quiescence, senescence, autophagy, cellular metabolism, and enhanced tumor cell immunogenicity. These mechanisms may be driven by interactions with unexpected targets. We review cellular responses to the Food and Drug Administration‐approved CDK4/6 inhibitors palbociclib, ribociclib, and abemaciclib, and summarize available knowledge of other drugs undergoing clinical trials, including data on their off‐target landscapes. We emphasize the importance of comprehensively characterizing drugs' selectivity profiles to maximize their clinical efficacy and safety and to facilitate their repurposing to treat additional diseases based on their target spectrum.