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The pleiotropic role of transcription factor STAT3 in oncogenesis and its targeting through natural products for cancer prevention and therapy
Author(s) -
Garg Manoj,
Shanmugam Muthu K.,
Bhardwaj Vipul,
Goel Akul,
Gupta Rajat,
Sharma Arundhiti,
Baligar Prakash,
Kumar Alan Prem,
Goh Boon Cher,
Wang Lingzhi,
Sethi Gautam
Publication year - 2021
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.21761
Subject(s) - stat3 , biology , transcription factor , stat protein , signal transduction , carcinogenesis , cancer research , tumor microenvironment , angiogenesis , cancer cell , microbiology and biotechnology , cell signaling , immune system , cancer , immunology , genetics , gene
Signal transducer and activator of transcription 3 (STAT3) is one of the crucial transcription factors, responsible for regulating cellular proliferation, cellular differentiation, migration, programmed cell death, inflammatory response, angiogenesis, and immune activation. In this review, we have discussed the classical regulation of STAT3 via diverse growth factors, cytokines, G‐protein‐coupled receptors, as well as toll‐like receptors. We have also highlighted the potential role of noncoding RNAs in regulating STAT3 signaling. However, the deregulation of STAT3 signaling has been found to be associated with the initiation and progression of both solid and hematological malignancies. Additionally, hyperactivation of STAT3 signaling can maintain the cancer stem cell phenotype by modulating the tumor microenvironment, cellular metabolism, and immune responses to favor drug resistance and metastasis. Finally, we have also discussed several plausible ways to target oncogenic STAT3 signaling using various small molecules derived from natural products.