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Optimizing clinical research procedures in public health emergencies
Author(s) -
Madariaga Ainhoa,
Kasherman Lawrence,
Karakasis Katherine,
Degendorfer Pamela,
Heesters Ann M.,
Xu Wei,
Husain Shahid,
Oza Amit M.
Publication year - 2021
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.21749
Subject(s) - public health , pandemic , clinical trial , medicine , health care , bridge (graph theory) , disease , covid-19 , intensive care medicine , political science , nursing , infectious disease (medical specialty) , pathology , surgery , law
Public Health Emergencies of International Concern, such as the coronavirus disease 2019 pandemic, have a devastating impact on an individual and societal level, and there is an urgent need to learn, understand and bridge the therapeutic gap at a time of extreme stress on the patient, health care systems and staff. Well‐designed, controlled clinical trials play a crucial role in the discovery of novel diagnostic and management strategies; however, these catastrophic circumstances pose unique challenges in initiating research studies at institutional, national, and international levels, highlighting the importance of a coordinated, collaborative approach. This review discusses key elements necessary to consider for developing clinical trials within a Public Health Emergency setting.