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In a search for efficient treatment for amyotrophic lateral sclerosis: Old drugs for new approaches
Author(s) -
Kukharsky Michail S.,
Skvortsova Veronika I.,
Bachurin Sergey O.,
Buchman Vladimir L.
Publication year - 2021
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.21725
Subject(s) - amyotrophic lateral sclerosis , drug repositioning , medicine , repurposing , neuroscience , immune system , multiple sclerosis , central nervous system , drug , bioinformatics , biology , disease , pharmacology , immunology , pathology , ecology
Recent progress in understanding the pathological changes in the nervous system and in certain other body systems (e.g., immune system) that lead to the development and progression of amyotrophic lateral sclerosis (ALS) revealed a number of molecular and cellular processes that can potentially be used as therapeutic targets. Many of these processes are compromised not only in ALS but also in other diseases and a repertoire of drugs able to restore, at least partially, their functionality has been developed. In this review, we briefly describe current approaches to the repurposing of such “old” drugs for treatment of patients with ALS.