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Pharmacotranscriptomics of peptide drugs with neuroprotective properties
Author(s) -
Dergunova Lyudmila V.,
Filippenkov Ivan B.,
Limborska Svetlana A.,
Myasoedov Nikolai F.
Publication year - 2021
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.21704
Subject(s) - neuroprotection , peptide , neuroscience , pharmacology , biology , computational biology , microbiology and biotechnology , biochemistry
Here we present a review of studies on the effects of peptides with neuroprotective properties on gene transcription in nerve cells. The few published works in this area clearly demonstrate massive changes in cell transcriptomes induced by peptides under normal conditions and under conditions of experimental brain ischemia. These changes significantly affect signaling and metabolic pathways, affecting various body systems and confirming the multiple target actions of peptides. The importance of noncoding RNAs in the regulation of these processes is shown, and we discuss the prospects of research for determining the main mechanisms of peptide regulation, which is necessary for the further development of drugs with targeted neuroprotective effects.