Premium
Biologically active isoquinoline alkaloids covering 2014–2018
Author(s) -
Shang XiaoFei,
Yang ChengJie,
MorrisNatschke Susan L.,
Li JunCai,
Yin XiaoDan,
Liu YingQian,
Guo Xiao,
Peng JingWen,
Goto Masuo,
Zhang JiYu,
Lee KuoHsiung
Publication year - 2020
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.21703
Subject(s) - isoquinoline , antifungal , antiparasitic , alkaloid , pharmacology , chemistry , traditional medicine , biology , stereochemistry , medicine , microbiology and biotechnology , pathology
Isoquinoline alkaloids, an important class of N ‐based heterocyclic compounds, have attracted considerable attention from researchers worldwide since the early 19th century. Over the past 200 years, many compounds from this class were isolated, and most of them and their analogs possess various bioactivities. In this review, we survey the updated literature on bioactive alkaloids and highlight research achievements of this alkaloid class during the period of 2014–2018. We reviewed over 400 molecules with a broad range of bioactivities, including antitumor, antidiabetic and its complications, antibacterial, antifungal, antiviral, antiparasitic, insecticidal, anti‐inflammatory, antioxidant, neuroprotective, and other activities. This review should provide new indications or directions for the discovery of new and better drugs from the original naturally occurring isoquinoline alkaloids.