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Emerging use of senolytics and senomorphics against aging and chronic diseases
Author(s) -
Martel Jan,
Ojcius David M.,
Wu ChengYeu,
Peng HsinHsin,
Voisin Laurent,
Perfettini JeanLuc,
Ko YunFei,
Young John D.
Publication year - 2020
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.21702
Subject(s) - disease , fisetin , medicine , cancer , fibrosis , mechanism (biology) , apoptosis , senescence , diabetes mellitus , wound healing , cancer research , bioinformatics , immunology , biology , endocrinology , antioxidant , quercetin , genetics , biochemistry , philosophy , epistemology
Senescence is a state of cell cycle arrest that plays an important role in embryogenesis, wound healing and protection against cancer. Senescent cells also accumulate during aging and contribute to the development of age‐related disorders and chronic diseases, such as atherosclerosis, type 2 diabetes, osteoarthritis, idiopathic pulmonary fibrosis, and liver disease. Molecules that induce apoptosis of senescent cells, such as dasatinib, quercetin, and fisetin, produce health benefits and extend lifespan in animal models. We describe here the mechanism of action of senolytics and senomorphics, many of which are derived from plants and fungi. We also discuss the possibility of using such compounds to delay aging and treat chronic diseases in humans.