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Gut microbiome interventions in human health and diseases
Author(s) -
Nie Pengqing,
Li Zhiqiang,
Wang Yimeng,
Zhang Yubing,
Zhao Mengna,
Luo Jie,
Du Shiming,
Deng Zixin,
Chen Jincao,
Wang Yunfu,
Chen Shi,
Wang Lianrong
Publication year - 2019
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.21584
Subject(s) - dysbiosis , microbiome , disease , gut flora , gut microbiome , biology , immune system , pathogenesis , immunology , bioinformatics , medicine , pathology
Ongoing studies have determined that the gut microbiota is a major factor influencing both health and disease. Host genetic factors and environmental factors contribute to differences in gut microbiota composition and function. Intestinal dysbiosis is a cause or a contributory cause for diseases in multiple body systems, ranging from the digestive system to the immune, cardiovascular, respiratory, and even nervous system. Investigation of pathogenesis has identified specific species or strains, bacterial genes, and metabolites that play roles in certain diseases and represent potential drug targets. As research progresses, gut microbiome–based diagnosis and therapy are proposed and applied, which might lead to considerable progress in precision medicine. We further discuss the limitations of current studies and potential solutions.