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Roles of microRNAs in T cell immunity: Implications for strategy development against infectious diseases
Author(s) -
Giri Bikash R.,
Mahato Ram I.,
Cheng Guofeng
Publication year - 2019
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.21539
Subject(s) - microrna , biology , immunity , immune system , extracellular vesicle , mechanism (biology) , function (biology) , microvesicles , cell , immunology , computational biology , microbiology and biotechnology , gene , genetics , philosophy , epistemology
T cell immunity plays a vital role in pathogen infections. MicroRNA (miRNAs) are small, single‐stranded noncoding RNAs that regulate T cell immunity by targeting key transcriptional factors, signaling proteins, and cytokines associated with T cell activation, differentiation, and function. The dysregulation of miRNA expression in T cells may lead to specific immune responses and can provide new therapeutic opportunities against various infectious diseases. Here, we summarize recent studies that focus on the roles of miRNAs in T cell immunity and highlight miRNA functions in prevalent infectious diseases. Additionally, we also provide insights into the functions of extracellular vesicle miRNAs and attempt to delineate the mechanism of miRNA sorting into extracellular vesicles and their immunomodulatory functions. Moreover, methodologies and strategies for miRNA delivery against infectious diseases are summarized. Finally, potential strategies for miRNA‐based therapies are proposed.