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Biologically active quinoline and quinazoline alkaloids part II
Author(s) -
Shang XiaoFei,
MorrisNatschke Susan L.,
Yang GuanZhou,
Liu YingQian,
Guo Xiao,
Xu XiaoShan,
Goto Masuo,
Li JunCai,
Zhang JiYu,
Lee KuoHsiung
Publication year - 2018
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.21492
Subject(s) - antifungal , quinoline , quinazoline , antiparasitic , biological activity , chemistry , pharmacology , combinatorial chemistry , biology , medicine , biochemistry , organic chemistry , microbiology and biotechnology , in vitro , pathology
To follow‐up on our prior Part I review, this Part II review summarizes and provides updated literature on novel quinoline and quinazoline alkaloids isolated during the period of 2009‒2016, together with the biological activity and the mechanisms of action of these classes of natural products. Over 200 molecules with a broad range of biological activities, including antitumor, antiparasitic and insecticidal, antibacterial and antifungal, cardioprotective, antiviral, anti‐inflammatory, hepatoprotective, antioxidant, anti‐asthma, antitussive, and other activities, are discussed. This survey should provide new clues or possibilities for the discovery of new and better drugs from the original naturally occurring quinoline and quinazoline alkaloids.