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Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives
Author(s) -
Xiao Sulong,
Tian Zhenyu,
Wang Yufei,
Si Longlong,
Zhang Lihe,
Zhou Demin
Publication year - 2018
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.21484
Subject(s) - betulinic acid , oleanolic acid , broad spectrum , ursolic acid , triterpenoid , biology , mechanism of action , drug , terpene , mechanism (biology) , pharmacology , computational biology , chemistry , stereochemistry , biochemistry , combinatorial chemistry , medicine , botany , philosophy , epistemology , genetics , alternative medicine , pathology , in vitro
Viral infections cause many serious human diseases with high mortality rates. New drug‐resistant strains are continually emerging due to the high viral mutation rate, which makes it necessary to develop new antiviral agents. Compounds of plant origin are particularly interesting. The pentacyclic triterpenoids (PTs) are a diverse class of natural products from plants composed of three terpene units. They exhibit antitumor, anti‐inflammatory, and antiviral activities. Oleanolic, betulinic, and ursolic acids are representative PTs widely present in nature with a broad antiviral spectrum. This review focuses on the recent literatures in the antiviral efficacy of this class of phytochemicals and their derivatives. In addition, their modes of action are also summarized.