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Toward Hydrogen Sulfide Based Therapeutics: Critical Drug Delivery and Developability Issues
Author(s) -
Zheng Yueqin,
Yu Bingchen,
La Cruz Ladie Kimberly,
Roy Choudhury Manjusha,
Anifowose Abiodun,
Wang Binghe
Publication year - 2018
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.21433
Subject(s) - cytoprotection , nitric oxide , pharmacology , drug delivery , drug , hypoxia (environmental) , context (archaeology) , mediator , hydrogen sulfide , oxidative stress , medicine , chemistry , biochemistry , biology , paleontology , organic chemistry , oxygen , sulfur
Hydrogen sulfide (H 2 S), together with nitric oxide (NO) and carbon monoxide (CO), belongs to the gasotransmitter family and plays important roles in mammals as a signaling molecule. Many studies have also shown the various therapeutic effects of H 2 S, which include protection against myocardial ischemia injury, cytoprotection against oxidative stress, mediation of neurotransmission, inhibition of insulin signaling, regulation of inflammation, inhibition of the hypoxia‐inducible pathway, and dilation of blood vessels. One major challenge in the development of H 2 S‐based therapeutics is its delivery. In this manuscript, we assess the various drug delivery strategies in the context of being used research tools and eventual developability as therapeutic agents.