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Strategies in the Design of Small‐Molecule Fluorescent Probes for Peptidases
Author(s) -
Chen Laizhong,
Li Jing,
Du Lupei,
Li Minyong
Publication year - 2014
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.21316
Subject(s) - small molecule , fluorescence , cleave , peptide , cell signaling , enzyme , amino acid , computational biology , cell , biology , biochemistry , signal transduction , chemistry , microbiology and biotechnology , physics , quantum mechanics
Peptidases, which can cleave specific peptide bonds in innumerable categories of substrates, usually present pivotal positions in protein activation, cell signaling and regulation as well as in the origination of amino acids for protein generation or application in other metabolic pathways. They are also involved in many pathological conditions, such as cancer, atherosclerosis, arthritis, and neurodegenerative disorders. This review article aims to conduct a wide‐ranging survey on the development of small‐molecule fluorescent probes for peptidases, as well as to realize the state of the art in the tailor‐made probes for diverse types of peptidases.