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Imaging EGFR and HER2 by PET and SPECT: A Review
Author(s) -
Corcoran Emily B.,
Hanson Robert N.
Publication year - 2014
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.21299
Subject(s) - molecular imaging , spect imaging , medicine , pet imaging , monoclonal antibody , positron emission tomography , nuclear medicine , medical physics , cancer research , antibody , in vivo , immunology , biology , microbiology and biotechnology
In an effort to discover a noninvasive method for predicting which cancer patients will benefit from therapy targeting the EGFR and HER2 proteins, a large body of the research has been conducted toward the development of PET and SPECT imaging agents, which selectively target these receptors. We provide a general overview of the advances made toward imaging EGFR and HER2, detailing the investigation of PET and SPECT imaging agents ranging in size from small molecules to monoclonal antibodies.