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Modern lipid‐, carbohydrate‐, and peptide‐based delivery systems for peptide, vaccine, and gene products
Author(s) -
Simerska Pavla,
Moyle Peter M.,
Toth Istvan
Publication year - 2011
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.20191
Subject(s) - lipid anchored protein , peptide , gene delivery , glycosylation , peptide vaccine , delivery system , gene , biochemistry , biology , computational biology , chemistry , genetic enhancement , pharmacology , immunology , antibody , epitope , apoptosis , autophagy
Research related to peptide, vaccine, and gene delivery has grown exponentially over the last decade. In this review, we discuss the development of delivery systems for peptides, gene and vaccine products. Special focus is given to different lipidation and glycosylation strategies to improve the metabolic stability and membrane permeability of therapeutics, and their targeting to specific sites. The synthetic methods for preparation of the systems are also described. © 2009 Wiley Periodicals, Inc. Med Res Rev, 31, No. 4, 520–547, 2011