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Pharmacological and therapeutic secrets of plant and brain (endo)cannabinoids
Author(s) -
Hanuš Lumír Ondřej
Publication year - 2009
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.20135
Subject(s) - anandamide , endocannabinoid system , cannabis sativa , synthetic cannabinoids , cannabinoid , pharmacology , cannabinoid receptor , cannabis , neuroscience , chemistry , biology , medicine , psychiatry , biochemistry , botany , receptor , agonist
Research on the chemistry and pharmacology of cannabinoids and endocannabinoids has reached enormous proportions, with approximately 15,000 articles on Cannabis sativa L . and cannabinoids and over 2,000 articles on endocannabinoids. The present review deals with the history of the Cannabis sativa L . plant, its uses, constituent compounds and their biogeneses, and similarity to compounds from Radula spp. In addition, details of the pharmacology of natural cannabinoids, as well as synthetic agonists and antagonists are presented. Finally, details regarding the pioneering isolation of the endocannabinoid anandamide, as well as the pharmacology and potential therapeutic uses of endocannabinoid congeners are presented. © 2008 Wiley Periodicals, Inc. Med Res Rev, 29, No. 2, 213–271, 2009