Premium
Inosine monophosphate dehydrogenase (IMPDH) as a target in drug discovery
Author(s) -
Shu Qingning,
Nair Vasu
Publication year - 2008
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.20104
Subject(s) - imp dehydrogenase , drug discovery , biochemistry , allosteric regulation , enzyme , inosine , cofactor , purine , nucleotide , biology , chemistry , pharmacology , medicine , gene , surgery , transplantation , mycophenolic acid
Inosine monophosphate dehydrogenase (IMPDH) is a key enzyme of de novo purine nucleotide biosynthesis and is viewed as an important target in the quest for discovery of drugs in the antiviral, antibacterial and anticancer therapeutic areas. This review focuses on the medicinal chemistry, drug discovery and chemical biology of IMPDH. Examples of IMP and cofactor site‐directed inhibitors, allosteric inhibitors and isoform‐selective inhibitors are presented. Comparison of IMPDHs from different organisms is also made to facilitate the design of species‐selective IMPDH inhibitors for drug discovery. Special emphasis in the review is placed on IMPDH from Mycobacterium tuberculosis . © 2007 Wiley Periodicals, Inc. Med Res Rev, 28, No. 2, 219–232, 2008