Premium
Anti‐influenza virus agents: Synthesis and mode of action
Author(s) -
Lagoja Irene M.,
De Clercq Erik
Publication year - 2008
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.20096
Subject(s) - mode of action , virus , virology , action (physics) , influenza a virus , orthomyxoviridae , medicine , pharmacology , chemistry , biology , biochemistry , physics , quantum mechanics
Abstract Annual epidemics of influenza virus infection are responsible for considerable morbidity and mortality, and pandemics are much more devastating. Considerable knowledge of viral infectivity and replication has been acquired, but many details still have to be elucidated and the virus remains a challenging target for drug design and development. This review provides an overview of the antiviral drugs targeting the influenza viral replicative cycle. Included are a brief description of their chemical syntheses and biological activities. For other reviews, see References.1–9 © 2006 Wiley Periodicals, Inc. Med Res Rev, 28, No. 1, 1–38, 2008