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New developments in natural products‐based anti‐AIDS research
Author(s) -
Yu Donglei,
MorrisNatschke Susan L.,
Lee KuoHsiung
Publication year - 2007
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.20075
Subject(s) - betulinic acid , natural product , drug discovery , drug , human immunodeficiency virus (hiv) , betulin , lead compound , computational biology , chemistry , pharmacology , drug candidate , combinatorial chemistry , traditional medicine , medicine , stereochemistry , biology , biochemistry , virology , in vitro , genetics
This review discusses anti‐HIV natural products from several compound classes, including terpenoids, coumarins, alkaloids, polyphenols, tannins, and flavonoids. Natural products can provide novel anti‐AIDS chemotherapeutic leads that are structurally unique or have new mechanisms of action. The drug discovery and development process proceeds from bioactivity‐directed isolation and identification of a promising lead natural product, followed by rational design‐based structural modification and structure–activity relationship analyses to optimize the lead compound as a drug candidate. This process is notably exemplified by the discovery of the modified betulinic acid derivative, DSB [PA‐457], which is currently in Phase II clinical trial and is the first‐in‐class HIV maturation inhibitor (MI). © 2006 Wiley Periodicals, Inc. Med Res Rev, 27, No. 1, 108–132, 2007