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Targeting EGFR and HER‐2 receptor tyrosine kinases for cancer drug discovery and development
Author(s) -
Kamath Shantaram,
Buolamwini John K.
Publication year - 2006
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.20070
Subject(s) - receptor tyrosine kinase , epidermal growth factor receptor , tyrosine kinase , growth factor receptor , targeted therapy , cancer research , receptor , drug discovery , erbb , ovarian cancer , pharmacology , egfr inhibitors , biology , cancer , signal transduction , medicine , bioinformatics , biochemistry
Conventional anticancer therapy using cytotoxic drugs lacks selectivity and is prone to toxicity and drug resistance. Anticancer therapies targeting aberrant growth factor receptor signaling are gaining interest. The erbB receptor family belongs to the type I, the receptor tyrosine kinases class, and comprises EGFR, HER‐2, HER‐3, and HER‐4. It has been targeted for solid tumor therapy, including breast, ovarian, colon, head‐and‐neck, and non‐small‐cell lung cancers. This review summarizes structural aspects of this class of growth factor receptors, their oncogenic expression, and various pharmacological interventions including biological products and small molecules that inhibit these enzymes. We have also discussed various mutations that occur in EGFR and their consequences on anticancer therapy. © 2006 Wiley Periodicals, Inc. Med Res Rev, 26, No. 5, 569–594, 2006