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An overview on the development of a bio‐artificial pancreas as a treatment of insulin‐dependent diabetes mellitus
Author(s) -
Silva Ana Isabel,
de Matos António Norton,
Brons I. Gabrielle,
Mateus Marília
Publication year - 2006
Publication title -
medicinal research reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.868
H-Index - 130
eISSN - 1098-1128
pISSN - 0198-6325
DOI - 10.1002/med.20047
Subject(s) - biocompatible material , artificial pancreas , insulin , immune system , diabetes mellitus , pancreas , transplantation , medicine , chemistry , immunology , endocrinology , type 1 diabetes , biomedical engineering
This paper presents the concept and most of the research undertaken all over the world for the development of a bio‐artificial pancreas (BAP) device over the last 30 years. The devices studied, meant to mimic the insulin secretion of the natural organ, were diverse and have been reviewed. Allogeneic or xenogeneic cells or cell clusters have been separated from the host's immune system by synthetic biocompatible semipermeable membranes to prevent the need, of the host, for immune‐suppressing regimens. The biocompatible polymer used as a barrier and its intrinsic characteristics, the cell immobilization or suspension media, the existence or not of co‐immobilized molecules or cells, the number of devices used and the implantation site, were addressed. © 2005 Wiley Periodicals, Inc. Med Res Rev